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Principles and Practice of Clinical Research
16 January 2011

Principles and Practice of Clinical Research

Principles and Practice of Clinical Research

2002 | 490 | ISBN: 0122740653 | PDF | 42 Mb

This timely book on how to conduct, evaluate, and monitor clinical research was written by leading experts in the field. An important strength of the book is that many of the authors are, or have been, associated with the National Institutes of Health (NIH). In fact, the text is based on a course given at the NIH and headed by the book's editor, John I. Gallin. The authors are particularly knowledgeable about NIH guidelines and regulations that govern much of the clinical research conducted in the United States. The book also contains valuable sections on how to obtain funding from the NIH for clinical research and is particularly strong in the area of ethical, regulatory, and legal issues. Given the problems with clinical research protocols that have been sufficiently serious to close down entire universities in recent years, this book clearly fulfills an important function for anyone involved in clinical research. The book is up to date and includes chapters on women and minorities, telemedicine, and animal models of human diseases, each of which is well written and informative. However, one or more separate chapters on the unique issues associated with genetics, genomics, and gene therapy would have been an appropriate and important addition to this otherwise comprehensive book. The concise initial chapters on bioethics, institutional review boards (IRBs), and data and safety monitoring provide important information needed to prepare investigators for conducting clinical research, at least as judged by the questions on several of the examinations that the NIH and my own institution require for certification to conduct clinical research. Chapter 8 presents the instructive story of the development of, and problems with, the antiviral drug fialuridine, which was ultimately found to have mitochondrial toxicity. The story is a voyage through all of the institutional and societal regulators. It is also a personal account told by a scientist who was in the middle of a stressful and at times tragic story. This chapter, like all the others, is focused on educating the reader, rather than pushing a political agenda, an approach in keeping with the spirit of the book and its roots in the NIH course on clinical research. A useful chapter written by two employees of the Food and Drug Administration describes the critical functions of this government agency in the regulation of drugs and biologic products. Although one could criticize the editor for relying so heavily on insiders to write chapters in the book, I think this is actually a strength. There are certainly many controversial issues that cause tensions between clinical researchers and the federal agencies that oversee clinical research, but the point of this book is to provide a road map that investigators can use to navigate the complexities of regulations governing clinical research. Who better to draw this map than the regulators themselves? This book will be accessible to a wide range of readers. Seasoned clinical investigators will find it a useful reference and a valuable teaching tool. Beginning students and others who are involved in clinical research but who may not have had formal training in the field will find that this book provides an excellent introduction to the key issues all clinical investigators must be familiar with. The book contains an enormous amount of useful information, which is clearly presented. For example, the chapters on legal issues are explained in terms that can readily be understood by a physician or a nurse with no legal training. Brief chapters on statistical methods cover the high points that any clinical investigator needs to be comfortable with, including randomization, calculation of the sample size, hypothesis testing, and survival analysis. The discussions of small and large clinical trials are of course generic and limited to addressing the more obvious aspects of designing trials. These chapters are not likely to obviate the need for an experienced, well-trained principal investigator to serve as a mentor for such endeavors. The brief overviews of technology transfer, telemedicine, and animal models of human disease cover topics that are so complex that entire books could be written about them. Somewhat out of place is the chapter on how to prepare scientific images for publication and display. The chapter is too brief to provide sufficiently detailed information for those not already well versed in the use of these techniques and is too superficial to interest anyone who is already producing scientific images on desktop computers. This book is much needed and provides essentially all of the basic information required by investigators involved in clinical research, from both a practical perspective and a regulatory perspective. Although it will not take the place of more in-depth books in any of the many areas it touches on, there is very little information in this well-written and comprehensive book that all clinical investigators should not be familiar with. Given the appropriate increase in attention to regulations governing clinical research, this book will be an important resource for institutional libraries and IRBs. It is an excellent starting point for those embarking on a clinical research project, as well as a valuable reference that experienced investigators will probably want to have readily available. ...
Clinical examination textbooks (including: physical examination, history taking, OSCEs)
1 November 2011

Clinical examination textbooks (including: physical examination, history taking, OSCEs)

clinical examination textbooks (including: physical examination, history taking, OSCEs) | 480.06 MB
Medical

COLLECTION CONTENTS
clinical. bickley (2009) bates guide to physical examination and history taking, 10th ed.chm
clinical. burton and burdi (2006) clinical skills for OSCEs, 2nd ed.pdf
clinical. douglas et al (2009) macleods clinical examination, 11th ed.pdf
clinical. gleadle (2003) history and examination at a glance.pdf
clinical. longmore et al (2007) oxford handbook of clinical medicine, 7th ed.chm
clinical. talley and oconnor (2007) clinical examination a systematic guide to physical diagnosis, 5th ed.chm
clinical. thomas and monaghan (2007) oxford handbook of clinical examination and practical skills, 1st ed.chm
Van Nostrand's Encyclopedia of Chemistry, 5th Edition
9 August 2011

Van Nostrand's Encyclopedia of Chemistry, 5th Edition
Van Nostrand's Encyclopedia of Chemistry, 5th Edition
English | Publisher: Wiley-Interscience; 5 edition (February 3, 2005) | PDF | 1856 Pages | 160.52 Mb

Scientists, engineers, and technologists in many fields need a knowledge of chemistry because of the importance of chemistry in diverse technologies. In addition, to "classical" topics of chemistry, the new Encyclopedia covers nanotechnology, fuel cell technology, green chemistry, forensic chemistry, supramolecular chemistry, combinatorial chemistry, materials chemistry, and proteomics.

This fifth print edition has been revised and updated, and includes over 200 new articles, as well as 1,300 updated articles.
Clinical Neuroanatomy, 26th Edition
16 March 2011

Clinical Neuroanatomy, 26th Edition

Clinical Neuroanatomy, 26th Edition by Stephen Waxman

McGraw-Hill Medical; 26 edition | July 10, 2009 | ISBN: 9780071603997 | 384 pages | PDF | 101 MB

For more than seventy years, Clinical Neuroanatomy has delivered a streamlined, comprehensive, and easy-to-remember synopsis of neuroanatomy and its functional and clinical applications. Emphasizing the most important concepts, facts, and structures, this well-illustrated and enjoyable-to-read text reflects the state-of-the-art in pathophysiology and the diagnosis and treatment of neurological disorders. Features that make Clinical Neuroanatomy perfect for board review or as a clinical refresher: Discussion of the latest advances in molecular and cellular biology in the context of neuroanatomy Clinical correlations to help you interpret and remember essential neuroanatomic concepts in terms of function and clinical application Numerous computed tomography (CT) and magnetic resonance images (MRIs) of the normal brain and spinal cord; functional magnetic resonance images that provide a noninvasive window on brain function; and neuroimaging studies that illustrate common pathological entities that affect the nervous system An Introduction to Clinical Thinking section that puts neuroanatomy in a unique clinical perspective Numerous tables that make the information clear and easy to remember A complete practice exam to test your knowledge Coverage of the basic structure and function of the brain, spinal cord, and peripheral nerves as well as clinical presentations of disease processes involving specific structures NEW full-color illustrations
Van Nostrand's Encyclopedia of Chemistry, 5th Edition
3 January 2011

Van Nostrand's Encyclopedia of Chemistry, 5th Edition

Van Nostrand's Encyclopedia of Chemistry, 5th Edition
Publisher: Wiley-Interscience | English | ISBN: 0471615250 | 1856 pages | PDF | 160.52 MB

Scientists, engineers, and technologists in many fields need a knowledge of chemistry because of the importance of chemistry in diverse technologies. In addition, to "classical" topics of chemistry, the new Encyclopedia covers nanotechnology, fuel cell technology, green chemistry, forensic chemistry, supramolecular chemistry, combinatorial chemistry, materials chemistry, and proteomics. This fifth print edition has been revised and updated, and includes over 200 new articles, as well as 1,300 updated articles.
Randomized Clinical Trials: Design, Practice and Reporting
23 October 2010

Randomized Clinical Trials: Design, Practice and Reporting

Randomized Clinical Trials: Design, Practice and Reporting by David Machin, Peter Fayers Wiley | 2010 | ISBN: 0471498122 | 374 pages | PDF | 12 MB
Using examples and case studies from industry, academia and research literature, Randomized Clinical Trials provides a detailed overview of the key issues involved in designing, conducting, analysing and reporting randomized clinical trials.? It examines the methodology for conducting Phase III clinical trials, developing the protocols, the practice for capturing, measuring, and analysing the resulting clinical data and their subsequent reporting.
Randomized clinical trials are the principal method for determining the relative efficacy and safety of alternative treatments, interventions or medical devices.? They are conducted by groups comprising one or more of pharmaceutical and allied health-care organisations, academic institutions, and charity supported research groups.? In many cases such trials provide the key evidence necessary for the regulatory approval of a new product for future patient use.? Randomized Clinical Trials provides comprehensive coverage of such trials, ranging from elementary to advanced level. Written by authors with considerable experience of clinical trials, Randomized Clinical Trials is an authoritative guide for clinicians, nurses, data managers and medical statisticians involved in clinical trials research and for health care professionals directly involved in patient care in a clinical trial context.
Clinical Chemistry: Techniques, Principles, Correlations (6th Edition)
3 February 2012

Clinical Chemistry: Techniques, Principles, Correlations (6th Edition)

Clinical Chemistry: Techniques, Principles, Correlations 6th Edition by Michael L. Bishop
Lippincott Williams & Wilkins | ISBN : 078179045X | 2009 | 788 pages | PDF | 44MB

In its Sixth Edition, this acclaimed text continues to be the most student-friendly clinical chemistry text available, featuring clear explanations that strike just the right balance of analytic principles, techniques, and correlation of results with disease states. All chapters have been thoroughly updated with the latest information as well as new case studies, practice questions, and exercises. This edition not only covers the how of clinical testing but also places greater emphasis on the what, why, and when in order to meet the needs of today's clinical laboratorians.
Tietz Fundamentals of Clinical Chemistry, 6 edition
8 January 2011

Tietz Fundamentals of Clinical Chemistry, 6 edition

Tietz Fundamentals of Clinical Chemistry, 6 edition by Carl A. Burtis PhD, Edward R. Ashwood MD, David E. Bruns MD

Publisher: Saunders | ISBN: 0721638651 | edition 2007 | Scan PDF | 970 pages | 120 mb

A condensed, student-friendly version of Tietz Textbook of Clinical Chemistry, this text uses a laboratory perspective to provide you with the chemistry fundamentals you need to work in a real-world, clinical lab. Accurate chemical structures are included to explain the key chemical features of relevant molecules. Offering complete, accurate coverage of key topics in the field, it's everything that you expect from the Tietz name!
Fundamentals of Analytical Chemistry, 9th edition
24 July 2013

Fundamentals of Analytical Chemistry, 9th edition
Douglas A. Skoog, Donald M. West and F. James Holler, "Fundamentals of Analytical Chemistry, 9th edition"
English | ISBN: 0495558281 | 2013 | PDF | 1072 pages | 106 MB


Known for its readability and systematic, rigorous approach, this fully updated FUNDAMENTALS OF ANALYTICAL CHEMISTRY, 9E, International Edition offers extensive coverage of the principles and practices of analytic chemistry and consistently shows students its applied nature. The book's award-winning authors begin each chapter with a story and photo of how analytic chemistry is applied in industry, medicine, and all the sciences. To further reinforce student learning, a wealth of dynamic photographs by renowned chemistry photographer Charlie Winters appear as chapter-openers and throughout the text. Incorporating Excel spreadsheets as a problem-solving tool, the Ninth Edition is enhanced by a chapter on Using Spreadsheets in Analytical Chemistry, updated spreadsheet summaries and problems, an "Excel Shortcut Keystrokes for the PC" insert card, and a supplement by the text authors, EXCEL(r) APPLICATIONS FOR ANALYTICAL CHEMISTRY, which integrates this important aspect of the study of analytical chemistry into the book's already rich pedagogy. New to this edition is OWL, an online homework and assessment tool that includes the Cengage YouBook, a fully customizable and interactive eBook, which enhances conceptual understanding through hands-on integrated multimedia interactivity.
Hutchison's Clinical Methods: An Integrated Approach to Clinical Practice
14 December 2010

Hutchison's Clinical Methods: An Integrated Approach to Clinical Practice
Hutchison's Clinical Methods: An Integrated Approach to Clinical Practice
Publisher: Saunders Ltd.; 22 edition | ISBN: 0702027995 | 2007 | CHM | 560 pages | 157MB

Hutchison's Clinical Methods, first published over a century ago, is the classic textbook on clinical examination. It provides an outstanding source of learning and reference for undergraduate medical students and postgraduate doctors. It seeks to teach an integrated approach to clinical practice, so that new methods and investigations are grafted onto established patterns of clinical practice, rather than added on as something extra. The text is organised so that both system-related and problem-oriented chapters are included. Particular emphasis is placed on the importance of the doctor-patient relationship, the essential skills needed for clinical examination, and for planning the appropriate choice of investigations in diagnosis and management.